Ketamine For Depression: What You Need To Know – Mayo Clinic Press

IV-infused ketamine is an FDA-approved anesthetic for surgical and medical procedures. In recent years, ketamine has increasingly been used as an antidepressant to treat TRD — considered off-label use. Ketamine delivered in low doses can provide rapid relief of TRD lasting for days to weeks.

https://mcpress.mayoclinic.org/living-well/ketamine-for-treatment-resistant-depression-what-you-need-to-know/